Immune-Mediated Inflammatory Skin Conditions (DERM)

TARGET DERM is now enrolling


Immune-Mediated Inflammatory Skin Conditions (IMISCs), including atopic dermatitis (AD), psoriasis, hidradenitis suppurativa (HS), vitiligo, and alopecia areata (AA), among others, are chronic inflammatory disorders affecting the skin and appendages. They constitute a substantial financial burden on the US health care system, and are among the greatest contributors to the burden of skin disease worldwide.

The TARGET-Dermatology Program (TARGET-DERM) is a cooperative consortium of principal investigators from academic institutions and community-based sites treating patients with IMISCs.  TARGET-DERM will provide unique opportunities to engage networked physician teams in evidence-based evaluation of IMISC therapy and involve these teams in the conduct of clinical research. We will leverage the multidisciplinary expertise within this network in biobanking, high-throughput technologies, and biomedical informatics to give investigators the power to analyze effectiveness and safety data at many different levels of resolution, ranging from subsets of patients to very large populations.  



  • Evaluate IMISC treatment regimens used in current clinical practice and examine initiation and uptake of newly approved medications
  • Evaluate patient outcomes and adverse events in clinical practice: predictors of therapeutic response
  • Examine populations under-represented in phase III clinical trials
  • Evaluate the relationship between IMISC and comorbid medical conditions
  • Evaluate Patient Reported Outcome (PRO) measures
  • Evaluate outcomes related to Patient Support Programs (PSPs)


Launching: Dec. 2018


Targeted number of patients: 15,000


TARGET-DERM Steering Committee


Emma Guttman, MD, PhD (Chair)
Professor of Dermatology and Clinical Immunology, The Mount Sinai Hospital

Eric Simpson, MD, MCR
Professor of Dermatology, Oregon Health & Science University

Jonathan Silverberg, MD, PhD, MPH
Assistant Professor of Dermatology, Medical Social Sciences and Preventive Medicine at Northwestern University

Katrina Abuabara, MD, PhD
Assistant Professor of Dermatology, University of California San Francisco

Amy Paller, MD
Walter J.Hamlin Professor of Dermatology and Pediatrics, Northwestern University

James Krueger, MD, PhD
D.Martin Carter Professor in Clinical Investigation, Dermatology, Rockefeller University

John Harris, MD, PhD
Assistant Professor in the Dermatology, University of Massachusetts

Diamant Thaci, MD
Professor and Head, University of Luebeck, Germany

Robert Bissonnette, MD
Innovaderm Research, Montreal, Canada

Larry Eichenfield, MD
Chief of Pediatric and Adolescent Dermatology at Rady Children's Hospital, San Diego and Vice Chair of the Department of Dermatology at UC San Diego School of Medicine